Dr Mick Urbaniak

Senior Lecturer

Research Overview

My laboratory uses a combination of chemical and biological approaches to understand biological systems at the molecular level. Our research is focused on tropical infectious diseases, primarily the clinically relevant parasite Trypanosoma brucei and closely related trypanosomatid species such as Leishmania. We are studying how the parasites are able to sense and respond to their host environment by using a combination of tools that include genetic, proteomic and chemical biology approaches. We aim to translate the results of this basic research into early-stage drug discovery.

Selected Publications

The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes
Sugden, C., Urbaniak, M.D., Araki, T., Williams, J.G. 15/02/2015 In: Molecular Biology of the Cell. 26, 4, p. 805-820. 16 p.
Journal article

Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei
Urbaniak, M., Ferguson, M.A.J., Martin, D.M.A. 14/03/2013 In: Journal of Proteome Research. 12, p. 2233-2244. 12 p.
Journal article

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei
Urbaniak, M.D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M.A.J., Frearson, J., Drewes, G. 16/11/2012 In: ACS Chemical Biology. 7, 11, p. 1858-1865. 8 p.
Journal article

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages
Urbaniak, M., Guther, M.L.S., Ferguson, M.A.J. 4/05/2012 In: PLoS ONE. 7, 5, 8 p.
Journal article

  • DSI - Health