Dr Mick Urbaniak

Senior Lecturer

Research Overview

My laboratory uses a combination of genetics, cell biology and proteomics approaches to understand biological systems at the molecular level. Our research is focused on tropical infectious diseases, primarily the clinically relevant parasite Trypanosoma brucei and related species such as Leishmania. We are studying how the parasites are able to sense and respond to their host environment, and aim to translate the results of this basic research into early-stage drug discovery.

Selected Publications

Organising the cell cycle in the absence of transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionally
Benz, C., Urbaniak, M. 12/12/2019 In: PLoS Pathogens. 15, 12, 27 p.
Journal article

Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3’UTR
Benz, C., Lo, W., Fathallah, N., Connor-Guscott, A., Benns, H.J., Urbaniak, M.D. 31/12/2018 In: PLoS ONE. 13, 12, 12 p.
Journal article

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M.D., Otto, T.D., Stojanovski, L., Simeons, F.R.C., Manthri, S., MacLean, L.M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S., Berriman, M., Drewes, G., Gray, D.W., Ghidelli-Disse, S., Dixon, S., Fiandor, J.M., Wyatt, P.G., Ferguson, M.A.J., Fairlamb, A.H., Miles, T.J., Read, K.D., Gilbert, I.H. 25/07/2018 In: Nature. 560, p. 192-197. 6 p.
Journal article

Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication
Benz, C., Dondelinger, F., McKean, P.G., Urbaniak, M.D. 14/12/2017 In: Scientific Reports. 7, 10 p.
Journal article

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