Dr Nikki Copeland

Lecturer in Biomedicine

Research Overview

My research aims to understand how DNA is replicated in mammalian cells. Each cell division requires the precise copying of the genome, failure to regulate this process leads to mutation and chromosome abnormalities that are associated with cancer.

The key research aims are to better understand the replication licensing and initiation process of DNA replication. Use of cell-based and cell-free DNA replication techniques provide powerful tools to monitor key regulatory steps in this process. The long term goal is to identify differences between regulation of DNA replication in cancerous cells and normal tissues, to identify new therapeutic targets.