Dr Panagiotis Kotsantis

Lecturer in Genome Stability and DNA Repair

Research Overview

My research group studies the DNA repair mechanisms that safeguard the stability of the genome in mammalian cells. Any perturbation of the physiological progression of the DNA replication machinery causes DNA replication stress, genome-wide or at telomeres, which is counteracted by several DNA repair pathways. Unresolved DNA replication stress leads to gradual accumulation of mutations and DNA damage that facilitate genomic instability, which appears at early stages of disease such as cancer, neurodegenerative disorders and immunodeficiency. By employing a wide range of molecular and cellular biology experimental approaches, with a focus on imaging and DNA fibre assay-based techniques, we are investigating DNA replication stress, RNA:DNA hybrid biology and telomere homeostasis. In depth understanding of the mechanisms that dictate genome stability can be exploited in developing novel targeted therapeutic treatments.

In2STEM
School Engagement

Lancaster Drug Discovery Group: Link Building and Grant Development Workshop
Participation in workshop, seminar, course

North West Cancer Research Symposium 2026
Participation in workshop, seminar, course

PhD viva examination
Examination

Genome Stability Network 2026
Participation in conference - Academic

Scientific Reports (Journal)
Publication peer-review

Imaging Techniques in Life Sciences
Business Course/Training

Imaging Techniques in Life Sciences
Invited talk

Birmingham Centre for Genome Biology Conference 2025
Participation in conference - Academic

In2STEM
School Engagement

North West Cancer Research Symposium
Participation in conference - Academic

Grant reviewer for UKRI
Review of Award Applications

BACR 65th Anniversary Meeting
Participation in conference - Academic

Cancer Gene Therapy (Journal)
Editorial activity

Nature Communications (Journal)
Publication peer-review

Nature Communications (Journal)
Publication peer-review

In2STEM
School Engagement

Cancer Gene Therapy (Journal)
Publication peer-review

Grant reviewer for Wellcome Trust
Review of Award Applications

Grant reviewer for UKRI
Review of Award Applications

Genome Stability Network
Participation in conference - Academic

Nature Communications (Journal)
Publication peer-review

Dr Martin Higgs' BLS seminar
Types of External academic engagement - Hosting an academic visitor

Cell Reports (Journal)
Publication peer-review

PDRA Independent Fellowship Workshop
Oral presentation

Cell Reports (Journal)
Publication peer-review

Lancaster Biosciences Network Symposium
Symposium

Dr Clare Davies' BLS seminar
Types of External academic engagement - Hosting an academic visitor

Oncogene (Journal)
Publication peer-review

Dr Aga Gambus' BLS seminar
Types of External academic engagement - Hosting an academic visitor

Grant reviewer for the Dutch Cancer Society - KWF
Review of Award Applications

  • Cancer Biology and Genome Stability