Dr Richard MortLecturer
Dr. Richard Mort took up his post as Lecturer in Biomedicine at Lancaster University in October 2016. He specialises in imaging based methods to understand development, tissue homoeostasis and disease with a particular interest in the melanocyte lineage.
Lab web pages: http://wp.lancs.ac.uk/mortlab/
Melanocytes and melanoma: Melanocytes are the cells in our skin and hair that produce pigment. Melanoma, a cancer of melanocytes, is one of the deadliest forms of skin cancer. Its incidence has increased 7-fold in men and 4-fold in women in the last 40-years. The risk of developing melanoma is exacerbated by exposure to UV radiation in sunlight/sunbed lamps. My research is concerned with the early development of the melanocyte lineage and the lineage relationships and behaviour of the adult melanocyte populations and their roles in melanoma.
Biosensors of tissue homoeostasis: Biosensors that mark cell cycle stage allow real time visualisation of cell cycle dynamics in cell culture, during embryonic development and in tissue homoeostasis. Fucci was developed by Prof. Atsushi Miyawaki and Dr. Asako Sakaue-Sawano (RIKEN, Japan) and incorporates genetically encoded probes that highlight G1 and S/G2/M phases of the cell cycle allowing live imaging. In collaboration with Prof. Miyawaki and Dr. Sakaue-Sawano I have developed polycistronic versions of these cell cycle probes allowing the generation of single Cre-inducible mouse strains. The first line developed (R26R-Fucci2a) is now available through the Riken BRC (RBRC06511) and EMMA (EM:08395) mouse repositories.
2019 - NWCR Equipment Round. £50, 000 (with £54, 000 LU Match Funding). Spinning Disc Confocal Microscope for superfast multichannel live imaging. Joint PI's Mort, R, Benedetto, A.
2019 - North West Cancer Research RDF Grant. £15, 030. Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies? Joint PI’s: Mort, R, Benedetto, A, Fielding, A.
2018 - Medical Research Council £5,000. Co-develop biomaterials that incorporate polymers that use electricity or light to stimulate the tissue. Joint PI’s: Hardy, J., Wright, K. & Mort, R.
2017 - North West Cancer Research (Project Grant). £251,264 (Grant 4). Development of mouse tail skin as a translational preclinical model for UV exposure and early melanomagenesis. Mort, R.L. and Allinson, S.
2014 - NC3Rs (Pilot Grant). Grant #NC/M001091/1 - £90,000 (Grant 3). EFucci an atlas of proliferation to reduce mouse usage in embryonic proliferation assays. Mort, R.L., Jackson, I.J., McConnell, G., Armit, C. and Baldock, R.
2013 - NC3Rs (Studentship). Grant #NC/K001612/1 - £90,000 (Grant 2). An integrated platform to assay melanoblast and melanoma invasion of epidermis in vitro. Mort, R. L., Jackson, I.J.
2011 - Medical Research Scotland (Project Grant). Grant #436FRG - £148,872 (Grant 1). An integrated multi disciplinary approach to model normal neural crest cell development and the abnormalities that contribute to human birth defects. Mort, R. L., Jackson, I.J. and Painter, K.
Biol 124 – Hormones and Development
Biol 272 – Cell Biology Techniques (Module Organiser)
Biol 211 – Cell Biology
Biol 303 – Cell Cycle and Stem Cells
Biol 461 – Introduction to Molecular Biology
LU Summer School in Biomedicine
PhD Supervision Interests
I can offer PhD and MSc by research projects on either melanocytes and melanoma or cell/tissue biosensors. Please contact me for further details.
NWCR Equipment grant: Spinning Disc Confocal Microscope for superfast multichannel live imaging
01/10/2019 → 31/03/2020
Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies?
01/07/2019 → 30/06/2020
MSI: Feasibility of developing light emitting wound care dressing
01/08/2018 → 31/03/2020
Proximity to Discover: Industry Engagement for Impact
31/03/2018 → 30/11/2019