Professor Peter Fielden

Professor, Head of Department

Research Overview

Peter Fielden's research is focused on Analytical Science – the quantitative measurement of chemical and biochemical species in a diversity of environments. Sensors and sensing systems based on electroanalysis enable the detection of very low concentrations of metal ions in solution through to process monitoring in water treatment. Electrokinetic separation systems, with a special emphasis on the technique of isotachophoresis, have been applied to a diverse range of measurement challenges. Such sensing and separation systems may be integrated with microfluidics and lab-on-a-chip devices. The fabrication of micro and nanostructures in polymers has enabled the development of a range of lab-on-a-chip measurement systems. Microfluidics has been applied to the generation of concentration profiles through fluidic resistor networks, and also to the generation of multiphase microfluidics (droplets) for very high-throughput analysis. This approach has is being applied to drug discovery, formulation and life-science research.

A miniaturized injection-moulded flow-cell with integrated conducting polymer electrodes for on-line electrochemical degradation of azo dye solutions
Mohammed Redha, Z., Abdulla Yusuf, H., Ahmed, H.A., Fielden, P.R., Goddard, N.J., Baldock, S.J. 5/02/2017 In: Microelectronic Engineering. 169, p. 16-23. 8 p.
Journal article

A novel reagentless glutamate microband biosensor for real-time cell toxicity monitoring
Hughes, G., Pemberton, R.M., Fielden, P.R., Hart, J.P. 24/08/2016 In: Analytica Chimica Acta. 933, p. 82-88. 7 p.
Journal article

Determination of pb(II) by sequential injection/stripping analysis at all-plastic electrochemical fluidic cells with integrated composite electrodes
Kokkinos, C., Economou, A., Goddard, N., Fielden, P.R., Baldock, S.J. 1/06/2016 In: Talanta. 153, p. 170-176. 7 p.
Journal article

An analytical study of the electrochemical degradation of methyl orange using a novel polymer disk electrode
Yusuf, H.A., Redha, Z.M., Baldock, S.J., Fielden, P.R., Goddard, N.J. 5/01/2016 In: Microelectronic Engineering. 149, p. 31-36. 6 p.
Journal article

The design, development and application of electrochemical glutamate biosensors
Hughes, G., Pemberton, R.M., Fielden, P.R., Hart, J.P. 8/12/2015 In: TrAC Trends in Analytical Chemistry.
Journal article

Artefacts at the liquid interface and their impact in miniaturized biochemical assay
Litten, B., Blackett, C., Wigglesworth, M., Goddard, N., Fielden, P. 09/2015 In: Biomicrofluidics. 9, 5, 10 p.
Journal article

Development of a novel reagentless, screen– printed amperometric biosensor based on glutamate dehydrogenase and NAD+, integrated with multi–walled carbon nanotubes for the determination of glutamate in food and clinical applications.
Hughes, G., Pemberton, R.M., Fielden, P., Hart, J.P. 09/2015 In: Sensors and Actuators B: Chemical. 216, p. 614-621. 8 p.
Journal article

Scaling-up ultrasound standing wave enhanced sedimentation filters
Prest, J., Brown, B.J.T., Fielden, P., Wilkinson, S.J., Hawkes, J.J. 02/2015 In: Ultrasonics. 56, p. 260-270. 11 p.
Journal article

Using Fourier transform IR spectroscopy to analyze biological materials
Baker, M.J., Trevisan, J., Bassan, P., Bhargava, R., Butler, H.J., Dorling, K.M., Fielden, P.R., Fogarty, S.W., Fullwood, N.J., Heys, K.A., Hughes, C., Lasch, P., Martin-Hirsch, P.L., Obinaju, B., Sockalingum, G.D., Sulé-Suso, J., Strong, R., Walsh, M.J., Wood, B.R., Gardner, P., Martin, F.L. 08/2014 In: Nature Protocols. 9, 8, p. 1771-1791. 21 p.
Journal article

Nonlinear interfacial wave phenomena from the micro- to the macro-scale geometry-induced oscillations of finite bubbles in microchannels
Jisiou, M., Dawson, G., Thompson, A.B., Mohr, S., Fielden, P., Hazel, A.L., Juel, A. 1/02/2014 In: Procedia IUTAM. 11, p. 81-88. 8 p.
Journal article

Electro-enzymatic viologen-mediated substrate reduction using pentaerythritol tetranitrate reductase and a parallel, segmented fluid flow system
Fisher, K., Mohr, S., Mansell, D., Goddard, N.J., Fielden, P.R., Scrutton, N.S. 1/06/2013 In: Catalysis Science and Technology. 3, 6, p. 1505-1511. 7 p.
Journal article

Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift
Edwards, F., Tsakmaka, C., Mohr, S., Fielden, P.R., Goddard, N.J., Booth, J., Tam, K.Y. 2013 In: The Analyst. 138, 1, p. 339-345. 7 p.
Journal article

Miniaturised free flow isotachophoresis of bacteria using an injection moulded separation device
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Goodacre, R., O'Connor, R., Brown, B.J.T. 15/08/2012 In: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 903, p. 53-59. 7 p.
Journal article

Thiocyanate and nitrite analysis using miniaturised isotachophoresis on a planar polymer chip
Prest, J.E., Baldock, S.J., Beardah, M.S., Doyle, S.P., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 7/08/2011 In: The Analyst. 136, 15, p. 3170-3176. 7 p.
Journal article

Determination of the potassium content of explosive residues using miniaturised isotachophoresis
Prest, J.E., Beardah, M.S., Baldock, S.J., Doyle, S.P., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 11/2010 In: Electrophoresis. 31, 22, p. 3775-3782. 8 p.
Journal article

Systematic linearisation of a microfluidic gradient network with unequal solution inlet viscosities demonstrated using glycerol
Yusuf, H.A., Baldock, S.J., Fielden, P.R., Goddard, N.J., Mohr, S., Brown, B.J.T. 05/2010 In: Microfluidics and Nanofluidics. 8, 5, p. 587-598. 12 p.
Journal article

Continuous two-phase flow miniaturised bioreactor for monitoring anaerobic biocatalysis by pentaerythritol tetranitrate reductase
Mohr, S., Fisher, K., Scrutton, N.S., Goddard, N.J., Fielden, P.R. 2010 In: Lab on a Chip. 10, 15, p. 1929-1936. 8 p.
Journal article

A miniaturised isotachophoresis method for magnesium determination
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 07/2009 In: Analytical and Bioanalytical Chemistry. 394, 5, p. 1299-1305. 7 p.
Journal article

Optical imaging and analytical modelling of the dynamic concentration gradient of viscous inlet solutions in a microfabricated network design
Yusuf, H.A., Baldock, S.J., Mohr, S., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 04/2009 In: Microelectronic Engineering. 86, 4-6, p. 1361-1364. 4 p.
Journal article

Hybrid microfluidic sensors fabricated by screen printing and injection molding for electrochemical and electrochemiluminescence detection
Redha, Z.M., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T., Haggett, B.G.D., Andres, R., Birch, B.J. 02/2009 In: Electroanalysis. 21, 3-5, p. 422-430. 9 p.
Journal article

Optimisation and analysis of microreactor designs for microfluidic gradient generation using a purpose built optical detection system for entire chip imaging
Yusuf, H.A., Baldock, S.J., Barber, R.W., Fielden, P.R., Goddard, N.J., Mohr, S., Brown, B.J.T. 2009 In: Lab on a Chip. 9, 13, p. 1882-1889. 8 p.
Journal article

Determination of chlorine containing species in explosive residues using chip-based isotachophoresis
Prest, J.E., Beardah, M.S., Baldock, S.J., Doyle, S.P., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 27/06/2008 In: Journal of Chromatography A. 1195, 1-2, p. 157–163. 7 p.
Journal article

Disposable electrochemical flow cells for catalytic adsorptive stripping voltammetry (CAdSV) at a bismuth film electrode (BiFE)
Naseri, N.G., Baldock, S.J., Economou, A., Goddard, N.J., Fielden, P.R. 06/2008 In: Analytical and Bioanalytical Chemistry. 391, 4, p. 1283-1292. 10 p.
Journal article

A versatile sample injection system for miniaturised isotachophoresis devices
Baldock, S.J., Fielden, P.R., Goddard, N.J., Kretschmer, H.R., Prest, J.E., Brown, B.J.T. 05/2008 In: Microelectronic Engineering. 85, 5-6, p. 1440-1442. 3 p.
Journal article

Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation
Yusuf, H.A., Baldock, S.J., Barber, R.W., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 05/2008 In: Microelectronic Engineering. 85, 5-6, p. 1265-1268. 4 p.
Journal article

Disposable injection-moulded cell-on-a-chip microfluidic devices with integrated conducting polymer electrodes for on-line voltammetric and electrochemiluminescence detection
Naseri, N.G., Baldock, S.J., Economou, A., Goddard, N.J., Fielden, P.R. 02/2008 In: Electroanalysis. 20, 4, p. 448-454. 7 p.
Journal article

Miniaturised isotachophoresis of DNA
Prest, J.E., Baldock, S.J., Day, P.J.R., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 13/07/2007 In: Journal of Chromatography A. 1156, 1-2, p. 154-159. 6 p.
Journal article

Free flow isotachophoresis in an injection moulded miniaturised separation chamber with integrated electrodes
Stone, V.N., Baldock, S.J., Croasdell, L.A., Dillon, L.A., Fielden, P.R., Goddard, N.J., Thomas, C.L.P., Brown, B.J.T. 2007 In: Journal of Chromatography A. 1155, 2, p. 199-205. 7 p.
Journal article

Rapid chloride analysis using miniaturised isotachophoresis
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Mohr, S., Brown, B.J.T. 30/06/2006 In: Journal of Chromatography A. 1119, 1-2, p. 183-187. 5 p.
Journal article

Inorganic arsenic and selenium determination using miniaturised isotachophoresis
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 11/2005 In: Microchimica Acta. 151, 3-4, p. 223-230. 8 p.
Journal article

Analysis of chloride, bromide and iodide using miniaturised isotachophoresis on a planar polymer chip
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 24/08/2005 In: The Analyst. 130, 10, p. 1375-1382. 8 p.
Journal article

Integrated low-cost leaky wavguide sensor for mu-TAS applications
Zourob, M., Mohr, S., Fielden, P., Goddard, N.J. 2005 In: Micro Total Analysis Systems 2004. Cambridge : Royal Society of Chemistry p. 461-463. 3 p. ISBN: 0-85404-896-0 (v. 2), 9780854048960 (v. 2).
Conference contribution

Analysis of amino acids by miniaturised isotachophoresis
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Treves Brown, B.J. 8/10/2004 In: Journal of Chromatography A. 1051, 1-2, p. 221-226. 6 p.
Journal article

Use of miniaturised isotachophoresis on a planar polymer chip to analyse transition metal ions in solutions from metal processing plants
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Kalimeri, K., Brown, B.J.T., Zgraggen, M. 27/08/2004 In: Journal of Chromatography A. 1047, 2, p. 289-298. 10 p.
Journal article

Novel variable volume injector for performing sample introduction in a miniaturised isotachophoresis device
Baldock, S.J., Fielden, P.R., Goddard, N.J., Kretschmer, H.R., Prest, J.E., Brown, B.J.T. 9/07/2004 In: Journal of Chromatography A. 1042, 1-2, p. 181-188. 8 p.
Journal article

Integrated isotachophoresis in a miniaturised format for the separation of heavy metal cations
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 2004 In: Canadian Journal of Analytical Sciences and Spectroscopy. 49, 3, p. 129-135. 7 p.
Journal article

Determination of the ascorbate content of photographic developer solutions using miniaturised isotachophoresis on a planar chip
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 24/07/2003 In: The Analyst. 128, 9, p. 1131-1136. 6 p.
Journal article

Determination of inorganic selenium species by miniaturised isotachophoresis on a planar polymer chip
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 05/2003 In: Analytical and Bioanalytical Chemistry. 376, 1, p. 78-84. 7 p.
Journal article

Integrated moulded polymer electrodes for performing conductivity detection on isotachophoresis microdevices
Baldock, S.J., Fielden, P.R., Goddard, N.J., Prest, J.E., Brown, B.J.T. 21/03/2003 In: Journal of Chromatography A. 990, 1-2, p. 11-22. 12 p.
Journal article

Miniaturised isotachophoretic analysis of inorganic arsenic speciation using a planar polymer chip with integrated conductivity detection
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 2003 In: Journal of Chromatography A. 990, 1-2, p. 325-334. 10 p.
Journal article

Bidirectional isotachophoresis on a planar chip with integrated conductivity detection
Prest, J.E., Baldock, S.J., Fielden, P.R., Goddard, N.J., Brown, B.J.T. 9/10/2002 In: The Analyst. 127, 11, p. 1413-1419. 7 p.
Journal article

Determination of metal cations on miniaturised planar polymeric separation devices using isotachophoresis with integrated conductivity detection
Prest, J.E., Baldock, S.J., Fielden, P.R., Brown, B.J.T. 12/03/2001 In: The Analyst. 126, 4, p. 433-437. 5 p.
Journal article

Single electrode conductivity detection for electrophoretic separation systems
Prest, J.E., Baldock, S.J., Bektas, N., Fielden, P.R., Brown, B.J.T. 19/03/1999 In: Journal of Chromatography A. 836, 1, p. 59-65. 7 p.
Journal article

Isotachophoresis on planar polymeric substrates
Baldock, S.J., Bektas, N., Fielden, P.R., Goddard, N.J., Pickering, L.W., Prest, J.E., Snook, R.D., Brown, B.J.T., Vaireanu, D.I. 1998 In: Micro Total Analysis Systems ’98. Dordrecht : Kluwer p. 359-362. 4 p.
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