Dr Alexandre Benedetto

Senior lecturer in Integrative Physiology

Current Teaching

BIOL100, 231, 300, 400 - Academic tutoring

BIOL364 - Biology of Ageing (Module organiser)

BIOL383 - Innovations in Biosciences (Module organiser)

BIOL387/389/390 - 3rd year lab project supervisor

BIOL461 - Fundamental Research Skills

BIOL466/469/470 - Msc/Msci lab project supervisor

SSM2 - Special Study Module for 2nd year medical students (Convenor)

UG/PG Biomedical and further study career adviser

Selected Publications

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies
Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A.F., Au, C., Zhang, Q., van Schelt, S., Petrache, A.L., Wang, H., de la Guardia, Y., Bar-Nun, S., Tyler, E., Wakelam, M.J., Gems, D. 20/08/2018 In: Current biology : CB. 28, 16, p. 2544-2556.e5. 13 p.
Journal article

New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging
Benedetto, A., Bambade, T., Au, C., Tullet, J.M., Monkhouse, J., Dang, H., Cetnar, K., Chan, B., Cabreiro, F., Gems, D. 1/10/2019 In: Aging Cell. 18, 5, 10 p.
Journal article

Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death
Galimov, E.R., Pryor, R.E., Poole, S.E., Benedetto, A., Pincus, Z., Gems, D. 6/03/2018 In: Cell Reports. 22, 10, p. 2730-2741. 12 p.
Journal article

Spatiotemporal control of gene expression using microfluidics
Benedetto, A., Accetta, G., Fujita, Y., Charras, G. 7/04/2014 In: Lab on a Chip. 14, 7, p. 1336-1347. 12 p.
Journal article

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans
Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M., Edwards, S., Fischer, G., Davidson, A., Pryor, R.E., Stevens, A., Slack, F.J., Tavernarakis, N., Braeckman, B.P., Schroeder, F.C., Nehrke, K., Gems, D. 23/07/2013 In: Plos Biology. 11, 7, 17 p.
Journal article

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
Kuriyama, S., Theveneau, E., Benedetto, A., Parsons, M., Tanaka, M., Charras, G., Kabla, A., Mayor, R. 7/07/2014 In: Journal of Cell Biology. 206, 1, p. 113-127. 15 p.
Journal article

Investigating the Interplay of Organoselenides in Metal Homeostasis and the Gut-Brain Axis for General and Brain Health
01/07/2024 → 01/07/2027
Research

LU BBSRC 2024 International Partnership Fund
01/04/2024 → 29/06/2024
Research

Designing bacterial gut communities to improve bee resilience to climate change
01/10/2023 → 30/09/2027
Research

High-resolution spatiotemporal mapping of brain and gut organismal death processes in C. elegans.
17/07/2023 → 17/07/2024
Research

Targeting the gut-brain axis to improve animal resilience to a warming climate
17/04/2023 → 31/07/2023
Research

Brazil-UK Partnership: New Bioactives for a Healthy Gut, targeting the gut microbiota
01/06/2022 → 31/05/2025
Research

Building and optimisation of a microscope stage mounted stretch apparatus to investigate the role of physical forces in melanoblast behaviour
01/11/2021 → 31/10/2022
Research

Integrated Multiomics of Host-bacteria Interactions during C. elegans Gut Infections
31/01/2020 → 30/04/2025
Research

NWCR Equipment grant: Spinning Disc Confocal Microscope for superfast multichannel live imaging
01/10/2019 → 31/03/2020
Research

Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies?
01/07/2019 → 30/09/2020
Research

Neuromodulation of death in Caenorhabditis elegans
18/03/2019 → 30/04/2022
Research

Neuromodulation of death in Caenorhabditis elegans
18/03/2019 → 30/04/2022
Research

Equipment: Cell microenvironment control platform for cancer biomedicine
28/09/2018 → 31/03/2019
Research

FHM PhD Studentship - Repurposing gemfibrozil as a treatment for Alzheimer’s disease (£66,336)
01/01/1900 → …
Research

LROs and Kynurenine Pathway in C. elegans-gut bacterium interactions
Invited talk

Étude des relations entre la prolifération et la différenciation cellulaire au cours de l'organogenèse intestinale chez C. elegans
Examination

Blue fluorescence sheds light on the gut brain axis in C. elegans
Invited talk

NeuRAL Network Engagement Event
Participation in workshop, seminar, course

Role of the kynurenine pathway in C. elegans host-gut bacterium interactions
Invited talk

Shedding light on death
Oral presentation

Dr Abi Spear visiting Lancaster University
Types of Business and Community - Hosting of external, non-academic visitor

Targeting the gut-brain axis to improve animal resilience to a changing climate
Invited talk

Grant Writing Workshop
Other

The host kynurenine pathway modulates and is modulated by gut microbes in C. elegans
Oral presentation

Zeiss Lattice Light Sheet 7 demonstration
Other

Targeting the gut-brain axis to improve resilience to climate change in model animals.
Symposium

A hitchhiker guide to academia
Invited talk

Careers in academia, a personal perspective
Invited talk

Landscape Report: Towards Bioprinting Devices In vivo
Consultancy

Bioimaging special seminar
Participation in workshop, seminar, course

Natalia da Silva Jardim
Hosting an academic visitor

C. elegans screening of bioactives and probiotics
Symposium

Optical Imaging Across Biological Length Scales: From Nanometers to Millimeters
Participation in workshop, seminar, course

UNIPAMPA-LU partnership visit to Magnitude Biosciences
Participation in workshop, seminar, course

C. elegans screening of bioactives and probiotics
Participation in workshop, seminar, course

Daiana Avila
Hosting an academic visitor

Sandra Haas
Hosting an academic visitor

Natalia da Silva Jardim
Hosting an academic visitor

Superfood for bugs: Understanding microbial nutrient requirements from a geometric perspective
Consultancy

National Mouse Genetic Network (External organisation)
Membership of network

Cognitive Frailty INterdisciplinary Network (External organisation)
Membership of network

External Examiner for Exeter Biosciences undergraduate programs
Examination

Knowledge Exchange activity with Advanced Medical Solutions
Types of Business and Community - Hosting of external, non-academic visitor

FEBS Open Bio (Journal)
Editorial activity

PLoS ONE (Journal)
Editorial activity

Sensors (Journal)
Publication peer-review

Institute of Healthy Ageing Alumni Symposium.
Symposium

Daiana Avila
Hosting an academic visitor

FEBS Open Bio (Journal)
Publication peer-review

BMC Genomics (Journal)
Publication peer-review

eLife (Journal)
Publication peer-review

PLoS ONE (Journal)
Publication peer-review

BLS Bioimaging academic lead
Other

Scientific Reports (Journal)
Publication peer-review

Neurotoxicity Research (Journal)
Publication peer-review

Centre for Ageing Research (Organisational unit)
Membership of network

Multi-Scale Biology Network Meeting
Participation in workshop, seminar, course

eLife (Journal)
Publication peer-review

Hindawi Publishing Corporation (Publisher)
Publication peer-review

Microfluidics and Nanofluidics (Journal)
Publication peer-review

Small (Journal)
Publication peer-review

Advanced Materials (Journal)
Publication peer-review

Biotechnology and Bioengineering (Journal)
Publication peer-review

Food and Chemical Toxicology (Journal)
Publication peer-review

Toxicological sciences : an official journal of the Society of Toxicology (Journal)
Publication peer-review

  • Ageing and Neuroscience
  • Cancer Biology and Genome Stability
  • Lancaster Intelligent, Robotic and Autonomous Systems Centre
  • LIRA - Biomedical
  • LIRA - Fundamentals
  • Microbes, Pathogens and Immunity