Dr Alexandre BenedettoSenior Lecturer
BIOL100, 231, 300, 400 - Academic tutoring
BIOL364 - Biology of Ageing (Module organiser)
BIOL383 - Innovations in Biosciences (Module organiser)
BIOL387/389/390 - 3rd year lab project supervisor
BIOL461 - Fundamental Research Skills
BIOL466/469/470 - Msc/Msci lab project supervisor
SSM2 - Special Study Module for 2nd year medical students (Convenor)
UG/PG Biomedical and further study career adviser
I wish to understand how animals and their microbiome communicate throughout life to maintain homeostasis. To probe such interactions, I study C. elegans and its adult gut microbiota under challenging conditions (infection, neurodegenerative diseases, stress, ageing). Combining genome-wide phenotyping screens, RNAseq and in chip time-lapse imaging, I aim to map the genetic network that governs worm gut-bacteria interactions (BBSRC: BB/S017127/1). In parallel, I also study the regulation of abrupt death in C. elegans in a bid to identify interventions that can halt or delay tissue decay and organismal death (Wellcome Trust: 214076/Z/18/Z). Lastly, I develop and apply microfludics and microfabricated devices for the quantitative study of cancer development and progression in cell and tissue culture models (NWCR). My lab heavily relies on live fluorescence microscopy and spectrometry approaches, using genetically encoded biosensors and reporters of cellular activities in bacteria, worms and mammalian cell cultures.
2019 - NWCR Equipment Round. £50,000 (+£56,000 LU match-funding). Spinning Disc Confocal Microscope for superfast multichannel live imaging. Joint PIs Mort, R, Benedetto, A.
2019 - North West Cancer Research Development Fund. £15, 030. Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies? Joint PIs: Mort, R, Benedetto, A, Fielding, A.
2019 - Biotechnology & Biological Sciences Research Council £741,000 (+£20,000 LU match-funding). Integrated multiomics of host-bacterium interactions during C. elegans gut infections. PI Benedetto A.
2018 - Wellcome Trust Seed Award in Sciences. £100,000 (+£11,000 LU match-funding). Neuromodulation of death in C. elegans. PI Benedetto A.
2018 - NWCR Capital Equiment Fund. £18,000 (+18,000 LU match-funding). A microfluidic temperature control platform for cancer biomedicine. PI Benedetto A.
PhD Supervision Interests
I can generally welcome PhD and MSc by Research students interested in studying: (1) the spatiotemporal dynamics of gut host-microbiota interactions in C. elegans, (2) the neuromodulation of organismal death in C. elegans, (3) the role of intercellular variability in cancer progression (in collaboration with Dr. Richard Mort). (4) cell bioenergetics in cancer and ageing (collaborations with Richard Mort and Aneta Stefanovska) Specific projects on offer for joining the lab in 2021-2022: (1) Genetically-encoded fluorescent biosensors for in vivo live monitoring of cell bioenergetics during C. elegans ageing. (2) Genetically-encoded fluorescent biosensors for in vivo live monitoring of skin cell bioenergetics during development, cancer and ageing (collaboration with Richard Mort). (3) Investigating the neuromodulation of organismal death with genetically-encoded fluorescent biosensors in C. elegans. (4) A fluorescent microbiota model for live monitoring of gut-microbe interactions during C. elegans ageing. For initial enquiries, students should email me at: email@example.com, referring to a specific MRes or PhD application in the email subject. CVs welcome.
C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies
Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A.F., Au, C., Zhang, Q., van Schelt, S., Petrache, A.L., Wang, H., de la Guardia, Y., Bar-Nun, S., Tyler, E., Wakelam, M.J., Gems, D. 20/08/2018 In: Current biology : CB. 28, 16, p. 2544-2556.e5. 13 p.
New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging
Benedetto, A., Bambade, T., Au, C., Tullet, J.M., Monkhouse, J., Dang, H., Cetnar, K., Chan, B., Cabreiro, F., Gems, D. 1/10/2019 In: Aging Cell. 18, 5, 10 p.
Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death
Galimov, E.R., Pryor, R.E., Poole, S.E., Benedetto, A., Pincus, Z., Gems, D. 6/03/2018 In: Cell Reports. 22, 10, p. 2730-2741. 12 p.
Spatiotemporal control of gene expression using microfluidics
Benedetto, A., Accetta, G., Fujita, Y., Charras, G. 7/04/2014 In: Lab on a Chip. 14, 7, p. 1336-1347. 12 p.
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans
Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M., Edwards, S., Fischer, G., Davidson, A., Pryor, R.E., Stevens, A., Slack, F.J., Tavernarakis, N., Braeckman, B.P., Schroeder, F.C., Nehrke, K., Gems, D. 23/07/2013 In: Plos Biology. 11, 7, 17 p.
In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
Kuriyama, S., Theveneau, E., Benedetto, A., Parsons, M., Tanaka, M., Charras, G., Kabla, A., Mayor, R. 7/07/2014 In: Journal of Cell Biology. 206, 1, p. 113-127. 15 p.
Integrated Multiomics of Host-bacteria Interactions during C. elegans Gut Infections
31/01/2020 → 31/07/2024
NWCR Equipment grant: Spinning Disc Confocal Microscope for superfast multichannel live imaging
01/10/2019 → 31/03/2020
Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies?
01/07/2019 → 30/09/2020
Neuromodulation of death in Caenorhabditis elegans
18/03/2019 → 17/09/2021
Equipment: Cell microenvironment control platform for cancer biomedicine
01/01/1900 → …
FHM PhD Studentship - Repurposing gemfibrozil as a treatment for Alzheimer’s disease (£66,336)
01/01/1900 → …
Knowledge Exchange activity with Advanced Medical Solutions
Types of Business and Community - Hosting of external, non-academic visitor
FEBS Open Bio (Journal)
PLoS ONE (Journal)
FEBS Open Bio (Journal)
BMC Genomics (Journal)
Scientific Reports (Journal)
Neurotoxicity Research (Journal)
Multi-Scale Biology Network Meeting
Participation in workshop, seminar, course
Hindawi Publishing Corporation (Publisher)
Microfluidics and Nanofluidics (Journal)
Advanced Materials (Journal)
Biotechnology and Bioengineering (Journal)
Food and Chemical Toxicology (Journal)
Toxicological sciences : an official journal of the Society of Toxicology (Journal)
- Lancaster Intelligent, Robotic and Autonomous Systems Centre