Seminar Abstract: "In my lab, we ask how cells can remember previous infections and how this leads to different responses to future challenges. In this talk, I will share studies that span traditional adaptive immune memory and provide evidence of memory within non-immune cells following an influenza virus infection. We use a variety of techniques including reporter animals, flow cytometry, imaging and spatial transcriptomics to interrogate the consequences of prior infection on long-term memory and the response to re-infection.".

Biosketch: Dr Megan MacLeod’s lab examine immunological memory: understanding how past infections and inflammatory insults affect subsequent immune responses. She has worked in the field of immune memory since her PhD at the University of Edinburgh in 2005. Megan continued to work on immune memory, focussing on CD4 T cells, during her postdoc with Pippa Marrack and John Kappler at National Jewish Health in Denver, CO, USA. She then joined the University of Glasgow in 2012 with a Career Development Research Fellowship from Arthritis Research UK to study the induction of tolerance in memory CD4 T cells. She is now a Professor at the University of Glasgow where her lab study the fundamental differences between naïve and memory T cells and investigate the interactions between immune cells and lung structural cells following viral infection.