Research projects and supervisors
The biggest considerations when choosing to study for an MSc, PhD or MPhil are the project and supervisor. You're very welcome to discuss research projects with potential supervisors. The most successful are defined by a distinct strength and knowledge of a subject area. The list of potential projects is indicative – please contact members of staff directly for more information.
Full staff list
Further contact details for Biomedical and Life Sciences staff can be found below.Our staff
I can welcome PhD and MSc by Research students interested in studying: - the spatiotemporal dynamics of gut host-microbiota interactions using a combination of advanced genomic, spectrophotometric and on-chip live-imaging microscopy techniques in the model organism C. elegans. - the dynamics of bacterial biofilm regulation in vivo in the model organism C. elegans. - the neuronal regulation of organismal death in C. elegans using advanced imaging of tissue-specific genetically-encoded calcium and pH reporters. - Autophagy and proteasome regulation in C. elegans - the role of intercellular variability in cancer progression using advanced live microscopy imaging and automated analysis techniques (in collaboration with Dr. Richard Mort). Contact and send your CV by email to email@example.com if interested!
Age is the major risk factor for the major causes of death in humans. Therefore I investigate the basic biology and the genetics of ageing. This is known as Biogerontology. My aim is to delay the onset of ageing-related changes so that healthy lifespan is extended. To discover and test potential drug targets and therapies I use the model organism Drosophila. I welcome enquiries from students interested in this rapidly moving and very exciting area.
I am happy to supervise PhD and MSc projects on the structure and function of protein-protein interactions or protein complexes, as well as bifunctional ligands inducing PPIs, ternary complexes, and induced protein degradation. I currently have a NWCR-funded PhD position available starting October 2020 exploring targeted protein degradation in head-and-neck squamous cell carcinoma (https://www.findaphd.com/phds/program/?i326p4675)
I am interested in prospective applications from any students whose background fits the work of The Institute for Social Futures (https://www.lancaster.ac.uk/social-futures/), particularly my own area of BioFutures, meaning any futurological scenario invoking any factor that is contingent upon our biological being-in-the-world, natural selection’s action upon us, our situation in a global ecosystem that contains millions of other species and the potential divergence of evolutionary interest between our species and others. The scope of BioFuture research therefore includes topics such as pandemic disease, the post-antibiotic world, life extension technologies, genetic modification and progeny selection, human life at higher average climate temperatures, extinctions and global food shortage.
I can offer PhD and MSc by research projects in the following areas of research: (1) The developmental cell biology of African trypanosomes. (2) Trypanosomes as models to study proteins implicated in human ciliary diseases. Please contact me for further details. (No funded positions are currently available).
Various Masters by Research and PhD projects are available on a self-funded basis including: Investigating the role of hypoxia-inducible factor in APP proteolysis in human cell culture and Drosophila models. Elucidating the role of dichloroacetate in the proteolysis of the Alzheimer's APP protein Investigating the synergistic effects of dichloroacetate and Notch inhibitors in relation to prostate cancer cell toxicity. The role of Jagged1 on prostate cancer metastasis.
Projects available in my lab include investigating the role of intestinal microbiota, and associated signaling pathways, in diseases such as cancer, inflammatory bowel disease and neurological conditions. I'm also interested in how microbes train the immune response to protect or predispose individuals to disease. Please contact me to discuss a specific area of study for PhD or Master by Research projects.
PhD positions and MSc Research posts are available in the Robinson laboratory in the following areas: (i) maintenance of genomic stability (DNA replication and repair mechanism) (ii) protein homeostasis (ubiquitin-like modifications and protein turnover). The laboratory specialises in the use of model archaeal systems to study these fundamental cellular processes which underpin a variety of disease states including cancer and neurodegeneration. Please email me for further information regarding funding and project specifics. http://www.lancaster.ac.uk/fhm/about-us/people/nicholas-robinson
My laboratory is seeking to recruit PhD and MRes students interested in the basic biology of Trypanosoma brucei and Leishmania species, which are the etiological agents of a number of diseases in developing countries. We can offer projects that use genetic, proteomic and biochemical approaches to study the parasites in vitro and in vivo. Please contact me for further details (No funded positions currently available).
Cannabinoid receptor signalling bias in ex vivo intestinal organoids. Importance of physiological levels of oxygen and energy sources in validating GI epithelial cell models of inflammation and cancer. Contribution of enteroendocrine cells to cannabinoid modulation of intestinal barrier permeability function (with John Worthington). Ethical considerations of human organoid donation and research (with Laura Machin and John Appleby). Impact of cannabinoids on free living ciliates (with Jackie Parry). Students can also apply for MSc by research for the last three projects.