Ageing and Neuroscience research
Our research focuses on:
- normal ageing in model organisms
- the molecular mechanisms leading to brain dysfunction and degeneration in various neuronal and psychiatric disorders.
Our research into the underlying processes of healthy ageing involves study of the processes leading to brain dysfunction and degeneration.
Progressive degeneration of the nervous system, and hence impaired cognition or movement, is a characteristic of conditions as Alzheimer’s disease, Parkinson’s disease and motor neurone disease.
We seek improved biomarkers for these diseases, and to develop new treatments by repurposing existing drugs or developing new ones, with the aim of taking these drugs into clinical trials.
In researching psychiatric disorders such as schizophrenia, we focus on the mechanisms through which genetic and environmental risk factors effect brain functioning and behaviour, and on identification of novel drugs to treat these disorders.
Members of the group also work on other age-related diseases, such as eye disease, osteoarthritis and cardiovascular disease.
Professor David Allsop: Protein misfolding and neurodegenerative disease; biomarkers; metals and reactive oxygen species
Dr Alexandre Benedetto: Fundamental mechanisms of stress resistance and ageing in C. elegans; integrated physiology approaches to C. elegans health, ageing and infections
Dr Sue Broughton: Drosophila models of ageing; role of insulin/IGF-like signalling pathway and diet in modulating lifespan
Dr David Clancy: Basic biology of ageing in model organisms; genetic modulators of ageing; drug modulators of ageing
Dr Neil Dawson: Preclinical models for psychiatric and neurodegenerative diseases; drug development
Dr Nigel Fullwood: Stem cell therapies for eye disease; artificial corneas
Dr Bob Lauder: Role of glycosaminoglycans in osteoarthritis; biomarkers
Dr Edward Parkin: Proteolysis of cell-surface proteins in neurodegenerative disease
Dr Alan Shirras: Acer and diet-dependent processes in Drosophila; insulin-like signalling and ageing in Drosophila