Claire Tinker-Mill

Associate Lecturer, Research Systems Administrator, PhD student

Thesis Title

Nanostructure and Characterisation of Amyloidβ

Nanomechanical and nanothermal mapping of initial stages of amyloid fibres formation
Kolosov, O., Tovee, P., Tinker-Mill, C., Allsop, D. 15/09/2014
Abstract

Amyloid-β fibrils in Alzheimer's Disease are not inert when bound to copper ions but can degrade hydrogen peroxide and generate reactive oxygen species
Mayes, J., Tinker-Mill, C., Kolosov, O., Zhang, H., Tabner, B., Allsop, D. 25/04/2014 In: Journal of Biological Chemistry. 289, p. 12052-12062. 11 p.
Journal article

Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation
Tinker-Mill, C., Mayes, J., Allsop, D., Kolosov, O. 2014 In: Scientific Reports. 4, 7 p.
Journal article

A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's Disease
Parthsarathy, V., McClean, P.L., Hölscher, C., Taylor, M., Tinker, C., Jones, G., Kolosov, O., Salvati, E., Gregori, M., Masserini, M., Allsop, D. 2013 In: PLoS ONE. 8, 1, 11 p.
Journal article

Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signalling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells
Parr-Sturgess, C.A., Tinker, C.L., Hart, C.A., Brown, M.D., Clarke, N.W., Parkin, E.T. 10/2012 In: Molecular Cancer Research. 10, 10, p. 1282-1293. 12 p.
Journal article

Nanoscale SPM characterisation of nacre aragonite plates and synthetic human amyloid fibres
Grishin, I., Tinker, C., Allsop, D., Robson, A., Kolosov, O. 2012 In: NSTI-Nanotech 2012. Santa Clara, USA : CRC PRESS-TAYLOR & FRANCIS GROUP p. 110-113. 4 p.
Paper