Dr Valon Llabjani

Honorary/Visiting

Research Interests

I work within the inter-disciplinary field of toxicology, cancer biology, analytical chemistry and biophysics. My main area of research involved the application and development of novel spectroscopic imaging approaches to derive biomarkers of effect in cells following chemical exposure, detect molecular alterations in disease, and to develop novel methods of growing 3D cell cultures to simulate in-vivo biological systems.

Main applications include identification of cancer associated biomarkers in histological samples, detection of chemical contaminants in biota, toxicity testing of chemical pollutants and nanoparticles on cells and polymer interactions with nanoparticles. For instance, I have been using ATR-FTIR, FTIR, Raman spectroscopy, GC-MS and IC-PMS, coupled with statistical analysis to identity polymer structures suitable form chemical diffusion as well as the manipulations of different polymers to support growth of biological cells.

Diagnostic segregation of human brain tumours using Fourier-transform infrared and/or Raman spectroscopy coupled with discriminant analysis
Gajjar, K., Heppenstall, L.D., Pang, W., Ashton, K.M., Trevisan, J., Patel, I.I., Llabjani, V., Stringfellow, H.F., Martin-Hirsch, P.L., Dawson, T., Martin, F.L., Llabjani, V. 2013 In: Analytical Methods. 5, 1, p. 89-102. 14 p.
Journal article

Differential Effects in Mammalian Cells Induced by Chemical Mixtures in Environmental Biota As Profiled Using Infrared Spectroscopy
Llabjani, V., Crosse, J.D., Ahmadzai, A.A., Patel, I.I., Pang, W., Trevisan, J., Jones, K.C., Shore, R.F., Martin, F. 15/12/2011 In: Environmental Science and Technology. 45, 24, p. 10706-10712. 7 p.
Journal article

Sublethal genotoxicity and cell alterations by organophosphorus pesticides in MCF-7 cells: implications for environmentally relevant concentrations
Ukpebor, J., Llabjani, V., Martin, F., Halsall, C.J. 2011 In: Environmental toxicology and chemistry / SETAC. 30, 3, p. 632-639. 8 p.
Journal article

Distinguishing cell types or populations based on the computational analysis of their infrared spectra
Martin, F., Kelly, J.G., Llabjani, V., Martin-Hirsch, P.L., Patel, I.I., Trevisan, J., Fullwood, N.J., Walsh, M.J. 11/2010 In: Nature Protocols. 5, 11, p. 1748-1760. 13 p.
Journal article

Syrian hamster embryo (SHE) assay (pH 6.7) coupled with infrared spectroscopy and chemometrics towards toxicological assessment
Trevisan, J., Angelov, P.P., Patel, I.I., Najand, G.M., Cheung, K.T., Llabjani, V., Pollock, H.M., Bruce, S.W., Pant, K., Carmichael, P.M., Scott, A.D., Martin, F.L. 11/2010 In: Analyst. 135, 12, p. 3266-3272. 7 p.
Journal article

Binary Mixture Effects by PBDE Congeners (47, 153, 183, or 209) and PCB Congeners (126 or 153) in MCF-7 Cells: Biochemical Alterations Assessed by IR Spectroscopy and Multivariate Analysis
Llabjani, V., Trevisan, J., Jones, K.C., Shore, R.F., Martin, F.L. 15/05/2010 In: Environmental Science and Technology. 44, 10, p. 3992-3998. 7 p.
Journal article

Tamoxifen induces a pro-apoptotic state in MCF-7 breast cells in the absence of marked decreases in survival.
Llabjani, V., Walsh, M., Singh, M., Martin-Hirsch, P.L., Martin, F.L. 1/09/2006 In: Toxicology. 226, 1, p. 56-57. 2 p.
Journal article