Dr Nicholas EvansSenior Lecturer, Head of Department
My supramolecular chemistry research interests encompass both host-guest recognition and self-assembly.
The study of molecular recognition, as carried out by supramolecular chemists, has to date largely focused on the binding and sensing of relatively "simple" targets such as metal cations or inorganic anions. Ultimately, I am aiming to prepare molecules or assemblies capable of the recognition of more challenging chemical targets, for example, ion pairs and chiral molecules. It is anticipated that the most promising of these receptors could then be incorporated into sensory devices for the guest species which they preferentially bind.
This research combines both synthetic and analytical chemistry skills, and its impact extends beyond the primary aim of molecular recognition with potential benefits to other areas of scientific investigation, including catalysis and pharmaceutical drug development.
Catenanes and rotaxanes are examples of interlocked molecules that are typically constructed by use of templated self-assembly processes. I am fascinated by the opportunities arising from the 3D structures of these remarkable molecules to create new receptors for functional applications.
However, to maximize these opportunities, synthetic routes to these interlocked molecules need to be rapid, scalable and allow for the incorporation of functionality to bind their target guests. Work carried out at Lancaster on the rapid synthesis of catenanes and rotaxanes has already been reported, and application of these methodologies to prepare receptors is in progress. In addition, one of these published methods has also been used to synthesize a mechanically chiral rotaxane and a peptide-displaying rotaxane.
For further information, see: http://supramolecularevans.com.
PhD Supervision Interests
I am looking to recruit postgraduate students keen to work on synthetic supramolecular chemistry research projects. Funded studentships will be advertised on the Lancaster Chemistry webpages when they are available. Prospective students with their own funding for postgraduate research should email me directly.
Anion Modulated Expression of Chirality in Hydrogen Bond Templated Mechanically Chiral Rotaxanes
Spicer, R.L., Shearman, C.C., Evans, N.H. 13/04/2023 In: Chemistry - A European Journal. 29, 21, 8 p.
Heteroditopic Rotaxanes and Catenanes for Ion Pair Recognition
Nicholson, S.J., Barlow, S.R., Evans, N.H. 12/01/2023
Hydrogen bond templated synthesis of catenanes and rotaxanes from a single isophthalic acid derivative
Barlow, S.R., Akien, G.R., Evans, N.H. 14/01/2023 In: Organic and Biomolecular Chemistry . 21, 2, p. 402-414. 13 p.
An amide hydrogen bond templated rotaxane displaying a peptide motif - demonstrating an expedient route to synthetic mimics of lasso peptides
Young, M.J., Akien, G.R., Evans, N.H. 21/07/2020 In: Organic and Biomolecular Chemistry . 18, 27, p. 5203-5209. 7 p.
Lanthanide-Containing Rotaxanes, Catenanes and Knots
Evans, N.H. 22/04/2020
Rapidly accessible "click" rotaxanes utilizing a single amide hydrogen bond templating motif
Fletcher, B.E., Peach, M.J.G., Evans, N.H. 7/04/2017 In: Organic and Biomolecular Chemistry . 15, 13, p. 2797-2803. 7 p.
Modulating the expression of chirality in a mechanically chiral rotaxane
Gell, C.E., McArdle-Ismaguilov, T.A., Evans, N.H. 7/02/2019 In: Chemical Communications. 55, 11, p. 1576-1579. 4 p.
Chiral catenanes and rotaxanes: fundamentals and emerging applications
Evans, N.H. 2/03/2018
The rapid synthesis and dynamic behaviour of an isophthalamide catenane
Marrs, C.N., Evans, N.H. 15/09/2015 In: Organic and Biomolecular Chemistry . p. 11021-11025. 5 p.
Advances in anion supramolecular chemistry: from recognition to chemical applications
Evans, N.H., Beer, P.D. 27/10/2014
Progress in the synthesis and exploitation of catenanes since the Millennium
Evans, N.H., Beer, P.D. 7/07/2014
Complete stereocontrol in the synthesis of macrocyclic lanthanide complexes: direct formation of enantiopure systems for circularly polarised luminescence applications
Evans, N.H., Carr, R., Delbianco, M., Pal, R., Yufit, D.S., Parker, D. 28/11/2013 In: Dalton Transactions. 42, 44, p. 15610-15616. 7 p.
Solution and surface-confined chloride anion templated redox-active ferrocene catenanes
Evans, N.H., Rahman, H., Leontiev, A.V., Greenham, N.D., Orlowski, G.A., Zeng, Q., Jacobs, R.M.J., Serpell, C.J., Kilah, N.L., Davis, J.J., Beer, P.D. 1/04/2012 In: Chemical Science. 3, 4, p. 1080-1089. 10 p.
A redox-active rotaxane capable of binding and electrochemically sensing chloride and sulfate anions
Evans, N.H., Serpell, C.J., Beer, P.D. 21/08/2011 In: Chemical Communications. 47, 31, p. 8775-8777. 3 p.
Chloride anion templated synthesis and crystal structure of a handcuff catenane
Evans, N.H., Serpell, C.J., Beer, P.D. 7/03/2011 In: Angewandte Chemie International Edition. 50, 11, p. 2507-2510. 4 p.
Exploring Rapidly Accessible Rotaxanes as Synthetic Mimics of Lasso Peptides
01/07/2020 → 30/06/2023
MSI: A novel coating technology based upon polyatomic ions from plasma
01/02/2019 → 30/04/2022
Macrocycles for Transmembrane Ion Pair Transportation – Towards New Treatments for Dysfunctional Ion Channels
01/01/1900 → …
Hosting an academic visitor
Johnson Matthey visit to Lancaster University.
Types of Business and Community - Hosting of external, non-academic visitor
- Chemical Synthesis