Biomedicine (Study Abroad) MSci - 2020 Entry

Course Structure

Lancaster University offers a range of programmes, some of which follow a structured study programme, and others which offer the chance for you to devise a more flexible programme to complement your main specialism. We divide academic study into two sections - Part 1 (Year 1) and Part 2 (Year 2, 3 and sometimes 4). For most programmes Part 1 requires you to study 120 credits spread over at least three modules which, depending upon your programme, will be drawn from one, two or three different academic subjects. A higher degree of specialisation then develops in subsequent years. For more information about our teaching methods at Lancaster please visit our Teaching and Learning section.

The following courses do not offer modules outside of the subject area due to the structured nature of the programmes: Architecture, Law, Physics, Engineering, Medicine, Sports and Exercise Science, Biochemistry, Biology, Biomedicine and Biomedical Science.

Information contained on the website with respect to modules is correct at the time of publication, and the University will make every reasonable effort to offer modules as advertised. In some cases changes may be necessary and may result in some combinations being unavailable, for example as a result of student feedback, timetabling, Professional Statutory and Regulatory Bodies' (PSRB) requirements, staff changes and new research.

Year 1

Core

• Anatomy and Tissue Structure

  In this module, the anatomy of the human body is explored. The module begins with an overview of the components of the eleven systems of the human body. The various types of body tissue are examined and their structure-function relationships investigated. Several body systems are explored in detail for example skeletal system, urinary system, integumentary (skin) system and muscular system. Finally, vision and hearing are discussed.

  In the laboratory, students will investigate blood, with emphasis on staining techniques used in order to identify types of white blood cells. In workshops, posters are prepared and PowerPoint presentations used to consolidate understanding of lecture material. A laboratory revision session is provided which enables examination of a range of tissues and organs, designed to aid revision of the major topics covered in this module.

• Biomedical Science in Practice

  This module aims to introduce Biomedical Science students to laboratory-based investigations of human health and disease.

  The basic principles of Cellular Pathology, Medical Microbiology, Clinical Biochemistry and Haematology and Transfusion Science are investigated. Laboratory practical work enables students to investigate Cellular Pathology, Medical Microbiology and Clinical Biochemistry.

  Students will develop an understanding of how common diseases such as cancer, chronic heart disease and diabetes mellitus develop. Finally, hospital-acquired infection will be explored. Understanding of several topics on this module will be consolidated during a case study workshop.

• Biomedicine and Society

  This module examines how biomedicine links into society. It initially looks at the historical developments of biomedicine, and key changes that have occurred often as a result of a dramatic change to society such as war. Students look at how ethics in particular have developed and how thinking and ultimately legislation has evolved in relation to unethical practice. Key ethical principles are explored in relation to both the treatment of humans and animals. To help understand the role of biomedicine in society the module examines the role of animals in experimentation, the ethics associated with running clinical trials with humans, issues related to contraception and the role the media plays in how society makes sense of developments in health care.

  The module has a main weekly lecture but much learning and consolidation of knowledge occurs in smaller seminar groups where students are given the opportunity to share their learning through presentations and debates.

• Biotechnology

  Biotechnology is one of the fastest moving fields in the biosciences. Genetic engineering techniques have allowed the manipulation of microorganisms, plants and animals to produce commercially important compounds, or to have improved characteristics. This module examines the techniques that are used in genetic manipulation and looks at examples of how the technology has been applied. The practical outcomes of genome sequencing projects and the way in which knowledge of the human genome can be applied to medicine and forensics are also considered. Practical classes and workshops allow students to perform some of the key techniques for themselves.

• Cell Structure and Function

  This module is an introduction to the structure and function of prokaryotic and eukaryotic cells. The first five lectures of the module will examine the main components of prokaryotic and eukaryotic cells and the way eukaryotic cells are organised into tissues. The techniques used to study cells will also be reviewed. The next two lectures will look in detail at the structure and function of mitochondria and chloroplasts and the chemiosmotic theory. This will be followed by a lecture on the way cells are organised into tissues. The final four lectures will cover reproduction in prokaryotic and eukaryotic cells and the eukaryotic cell cycle. The lectures are supplemented by two practical sessions, the first on light microscopic technique and the second covering organelle isolation

• Diagnosis in Biomedical Science

  This module will explore the theoretical basis for many methods routinely used in the medicine for diagnosis of immune system dysfunction, gastrointestinal tract diseases and endocrine disorders. The module will also enable investigation of methods employed to assess kidney function, haemostasis and drug use.

  During workshops, case studies will be used in order to apply new knowledge to real life examples and a practical session will give students the opportunity to carry out an ELISA experiment.

• Experimental Design and Data Analysis

  In this module students will be introduced to the basic principles of experimental research design. We familiarise students with the principals underpinning the statistical analysis of quantitative data using examples from experimental studies in practice. We also offer students the opportunity to use basic statistics to analyse experimental data using statistical software (IBM SPSS). These practical sessions give students an opportunity to acquire data analysis skills. We cover the logic behind generating and testing hypotheses in experimental design and provide students with guidance on how to critically appraise published experimental research.

  Students will gain an appreciation of the importance of experimental design in the study of human health; develop team-working skills; develop skills in self-directed learning using a virtual learning environment; experience the use of statistical software for performing statistical calculations; develop an ability to summarise and critique information from different sources in a coherent manner along with an understanding of how to report statistical results.

• Genetics

  This module examines the way in which genetic information, encoded by the DNA of the cell, is replicated and passed on to each new generation of cells and whole individuals. The ways in which genes affect the characteristics of a cell or organism are explored at the molecular level. The fundamentals of these processes are very similar in all organisms but the unique features of eukaryotes and prokaryotes are highlighted. We will also examine the consequences of mutation and look at some examples of diseases and conditions caused by defective genes and alterations in chromosome number or structure.

• Hormones and Development

  The aim of this module is to introduce students to the mechanisms cells use to communicate with one another.

  The structure and functions of several endocrine (hormone-producing) glands are investigated in lectures and workshops, such as the pituitary, thyroid and adrenal glands. The hormonal control of human reproduction is explained, followed by investigating the topic of fertilisation. Early embryogenesis is compared in a variety of organisms, supported by a laboratory session which enables a comparison of early embryogenesis in starfish, frog and chick. Finally, human pregnancy, development and fertility are examined with emphasis upon causes and treatment of infertility.

• Human Physiology

  Physiology is the study of how the body works, and is largely concerned with homeostasis – i.e. how body function is maintained at a relatively constant level in different environments and circumstances. This course considers the physiology of the brain and the nervous system; the heart and the circulatory system; the external respiratory system (lungs, together with transport of oxygen and carbon dioxide in the blood) and the gastrointestinal system. There is also some limited information on the pathophysiology of relevant human diseases. Other aspects of human physiology, involving different tissue and organ systems, are covered elsewhere.

  There is a workshop on neurophysiology (the Nernst equation), and practical classes that demonstrate the effects of exercise on blood pressure, the ABO blood grouping system, and the effects of pH on the activity of some key enzymes involved in digestion.

• Impact of Microbes

  This module introduces students to the world of microbiology. They will receive tuition from lecturers working on the cutting edge of microbiological research.

  Topics related to viruses, bacteria, fungi and protists will be covered. Hands on practical sessions will help students to understand the dynamics of bacterial growth, how to culture and count microbes, antibiotic resistance assays and identification of bacteria.

  Students will start to understand the mechanisms that bacteria use to cause human disease. Several fungi will be examined and students will learn how fungi are exploited in industry. Finally students are introduces to the protists; examine beautiful ciliates and flagellates and watch predatory protozoa in action.

• Infection and Immunity

  Covering a wide range of infectious organisms from viruses to worms, this module provides a comprehensive introduction to infection and immune responses of the host. The biology of the infecting organisms and the host’s immune response will both be examined as these are vital components in understanding the nature of the different types of infection.

  Selected infections will be studied in detail in lectures and practicals and used as paradigms to illustrate principles of the host/pathogen interaction.

• Molecules of Life

  In this module, students will explore the chemistry of some of the most important molecules to life, including water, nucleic acids, carbohydrates, proteins and lipids. The module begins with an overview of basic chemistry for example atomic structure, bonding, pH and molecular shape. It looks at the properties of water and how these enable water to support life. The structure and bonding within nucleic acids, proteins and carbohydrates are explored with emphasis upon how this is related to function within a cell. Finally, the structure and functions of lipids are described, with emphasis upon the role of lipids, proteins and carbohydrates in biological membranes.

  Workshops on this module enable use of RasMol molecular modelling software, making molecular models and problem-based learning.

• Protein Biochemistry

  The purpose of this module is to expand upon the introduction to proteins given in BIOL111. Our approach is to use specific examples to demonstrate different aspects of protein structure, and to illustrate the way that the different properties of individual amino acids contribute to the function of the proteins they make up. The course is split into two linked themes. Firstly, an introduction to the major structural features of proteins is given, with an emphasis on how protein structure relates to function. Secondly, an introduction to enzyme biochemistry is presented. We consider how enzymes catalyse biochemical reactions, how their activities can be described quantitatively, and how enzymes are regulated within the cell.

• Skills in Biomedical and Life Sciences

  This module introduces and provides training in the general skills necessary for the study of bioscience. These include use and care of laboratory equipment such as microscopes, spectrophotometers, micropipettes and centrifuges. It will also teach liquid-handling skills, and to calculate concentrations, volumes and dilution of solutions, particularly the importance and use of the mole concept. MS Excel will be used to generate statistics and to plot curves.

  The other main area covered is that of scientific reading and writing. You will learn to recognize good and bad sentences, use correct paragraph structure, to search for, acquire and know how to read scientific literature, and to avoid plagiarism. Finally students will learn the various forms in which science is communicated and the ways public understanding of scientific findings can be distorted.

  At the end of this module you will be able to record scientific investigation, collect data, present results, place them in the context of existing scientific literature and write a short scientific report.

Year 3

Core

• Biological Sciences Research Project

  The research project gives students first-hand experience of research and also the opportunity to be immersed in, and learn about, an area of work which is of current interest. Students plan, conduct and report on an open-ended investigation, often related to research interests of a member of staff. Projects cover a very wide variety of topics and may be carried out in a variety of ways. They involve a significant amount of original work and analysis to be carried out by students so that they gain experience in a range of skills, including experimental design and the testing of hypotheses. The results of the research are reported in an 8,000 word dissertation and an oral presentation.

• Cancer

  In this module students are given an overview of the cellular and molecular processes that underpin the development of cancer. This will enable students to discuss the various factors that can affect cancer susceptibility. Students will look at the approaches taken to treat cancer, including some of the new generation of molecularly-targeted cancer therapies.

• Medical Genetics

  This module aims to provide an understanding of the organisation of the human genome, how disease genes are mapped and how mutations are identified leading to the development of diagnostic tests. The impacts of massively parallel next generation DNA sequencing, microarrays and SNP genotyping on gene discovery and disease diagnosis are examined. The application of modern genetic techniques to identifying susceptibility genes for complex, multifactorial traits will also be studied. A range of diseases will be examined in detail both in lectures and in case study workshop sessions. The final lecture looks at gene therapy and considers the future for treatment of genetic disorders. The practical session aims to give students an opportunity to study their own DNA in a forensics scenario, using techniques that are widely applicable in modern molecular genetics.

Optional

• Biology of Ageing

  For 50 years, thanks to evolutionary theory, we’ve known why we are fated to age and die, but our understanding of the mechanisms has been a lengthy evolution in itself. Only relatively recently, with the use of modern molecular biology tools, do we begin to understand the mechanistic basis of the ageing process, from early notions about rates of living to current ideas about modular yet interacting mechanisms including autophagy, protein synthesis, nutrient sensing, insulin-like signalling and disease resistance. Even now we do not clearly know what makes us age. Ageing is perhaps the most multidisciplinary area of study and is certainly one of the last great mysteries in biology.

  This module introduces the area and the methodologies with which ageing is studied. Teaching is through lectures, workshops, practical work, individual and group-based coursework and private study.

• Cell Signalling

  The ability of cells to communicate with one another using signalling pathways is of fundamental importance in multicellular organisms such as mammals. Cell signalling enables the transmission of information that is required for the correct co-ordination of metabolism, growth and development.

  This module revises the basic principles of cellular communication, exploring the molecular basis of signalling in detail by using key signalling pathways as examples. The combination of Lectures and Workshops allows students to evaluate influential scientific discoveries, whilst Laboratory practicals provide the opportunity to put theory into practice.

• Cell Signalling, Transport and Disease

  This module explores some of the key roles played by ion channels and calcium ions in the communication that takes place within and between cells. The module is split into two linked themes. Firstly, an introduction to the diversity of ion channel families and their biological functions including the many different cellular processes throughout the life history of cells that are regulated by calcium ions as signals. Secondly, an investigation of the importance of ion channels and calcium signalling in animals, and human physiology in particular, using examples of diseases that are caused when ion channels malfunction (e.g. myotonia, malignant hyperthermia, sudden heart arrest caused by long QT syndrome.) or calcium signalling is disrupted (e.g. Alzheimer’s disease, polycystic kidney disease, pancreatitis). Students also gain hands-on experience of the techniques used to study ion channels and calcium signalling in cells.

• Clinical Immunology

  Every day our body does something remarkable, but we are completely unaware of it most of the time: our immune system is constantly protecting us from pathogens in our environment as well as threats from within. This highly evolved, interdependent collection of organs, cells and chemical messengers is continually scanning our tissues for any unwanted intruders or abnormal cells. When we get ill, with a cold for example, full mobilisation of our immune system sends armies of cells and molecules to fight the problem in what can sometimes literally be a fight to the death. Fortunately for us, our immune system wins the battle almost every time!

  In this module we examine the various components of the immune system – the organs, cells, and messengers, and how they function in health and illness. We look at particular threats such as allergies, infectious diseases and cancer, providing students with a good understanding of how this vital component of our bodies keeps us well.

• Environmental Pathogens

  Microbiology for the biomedical scientist comprises screening samples to identify and assess microbiological pathogens that cause disease and, enable front line medical staff to choose the correct therapy for successful eradication of the infection. Increasing numbers of these infections are community acquired and many are contracted from, or in, the environment. The environment therefore plays an increasing role in the life cycle and ecology of many pathogens. This in turn, is having an increasing impact on human health and national health services. The increase is a combination of changing environmental conditions (such as land use changes, global warming) and an ever evolving microbial community, most of which do not harm but a few can cause mild to fatal diseases when the opportunity arises. Also cycling in the environment are obligate pathogens which will cause infections if contracted. Furthermore, there are new diseases emerging (e.g. Ebola) and others thought to have been controlled are now re-emerging such as cholera. Using specific microbial pathogens as examples, this module examines the factors and interactions that allow microbial infections to be transmitted from the environment to humans and how their life cycle plays an important role in their emergence, persistence, transmission and infection. It also examines antibiotic resistance: how it has emerged, the different types of resistance, its management and the complications that it imposes on the treatment of these diseases. After attending this module you will still be able to go out into the natural environment but, as a result, you may be a little more cautious.

  Assessment:

  1. Exam: 2 hour paper with two questions in sections A and B and you are required to answer one question from each.

  2. Coursework is an extended essay of 2000 words based on the lectures and field trip. The title will be announced in the first lecture.

• Ethics in Biomedicine

  Research and practice in biomedicine continues to evolve more rapidly than at any other time in history, raising fascinating but complex moral and ethical challenges for those studying and working in the field. Understanding ethics in biomedicine and the relationship between science and society has become an essential element in biomedical degree training.

  This module builds on the Biomedicine and Society module, aiming to help students develop a deeper understanding of key ethical principles used in biomedicine and some major cultural, social and political influences that define research agendas and fuel ethical debates in the public perception of biomedicine.

  The module takes on a seminar format structured around three core themes:

  • The development of ethical principles in biomedicine
  • Ethical practice and current debates in animal and human research including clinical trials
  • Ethical challenges such as those emerging in genetics and regenerative medicine and how these are debated in the media.
• Genetics

  How is DNA, the fundamental building block of life, organised and expressed in different types of organisms such as bacteria and humans? Lectures comparing eukaryotic and prokaryotic gene organisation and expression, chromatin structure and DNA repair will seek to answer this question. In addition, you will study the application of genetics to science and technology during practical and workshop sessions, providing you with the opportunity to develop group and independent working skills whilst reinforcing theoretic concepts.

• Molecular and Biochemical Parasitology

  Students will be introduced to the importance of molecular, metabolic and cellular interactions within parasitic protists, and between a range of parasitic protists and their hosts.

  The course will provide students with an understanding of how the life cycle strategies used by protists enable them to gain access to, and survive within, the host as well as the impact that protist parasites have on human health. Practicals will provide an opportunity for students to apply immunological skills to investigate the host-parasite interaction.

• Neurobiology

  Nervous system function, from formation in the embryo to sensory systems and the neural control of complex behaviours, is the focus of this module. The emphasis is on model systems and the use of genetic tools to elucidate developmental pathways and neural circuits. Practical exercises are used to illustrate some of the functions of nervous systems and how these can be manipulated by genetic intervention.

  Students are encouraged to access and evaluate information from a variety of sources and to communicate the principles in a way that is well-organised, topical, and recognises the limits of current hypotheses. On completion of the module, students will be equipped with practical techniques including data collection, analysis and interpretation.

• Pathobiology

  This course considers the aetiology, pathogenesis, diagnosis and treatment of some of the major chronic diseases (excluding cancer) that affect human health, including: neurodegenerative conditions like Alzheimer’s and Parkinson’s disease; osteoarthritis and rheumatoid arthritis; cerebrovascular disease; and the two major types of diabetes. Some of the lectures are delivered by experts who treat patients with these diseases in local hospitals. Teaching is through lectures, practical work, and group-based student discussions and presentations.

  Talks given by the students themselves expand understanding to cover the pathobiology of many different chronic human diseases that are not covered formally in the lectures. There is also a practical class on diabetes that complements the lectures and teaches how some simple biochemical tests can be used for diagnosis and management of this condition.

• Proteins: Structure, Function & Evolution

  Understanding how life works depends to a great extent on understanding how proteins work. Thanks to the Human Genome Project, we now have a catalogue of all the proteins that are encoded in the human genome. This might be thought of as life’s toolbox. The next questions are: how do those tools work; how do they interact with each other; and how have they evolved over the billions of years of evolutionary time that have led to us? This module introduces modern techniques for the study of protein structure, function and evolution.

  Lectures cover: structural-functional relationships in proteins; methods for detecting the action of Darwinian selection in protein evolution; methods for reconstructing the evolutionary events that have led to present-day proteins; and, the new lab techniques that are allowing us to study protein function on a large scale. In the practical sessions, you will gain hands on experience of molecular phylogenetics – the main tool for studying evolution at the molecular level – as it is applied to proteins. Assessment is by an exam and a coursework essay on a protein of your choice, giving you a chance to apply your new knowledge of protein biochemistry to any of your own areas of interest in biology.

• Tropical Diseases

  This module is presented by academics with many years’ experience working on international tropical disease research. In the era of increasing international travel and trade, and considering the potential effects of climate change, parasites and pathogens that cause tropical diseases are an increasingly important group of organisms globally. These pathogens include viruses, bacteria, protists, worms and arthropods of various kinds.

  Students will focus on the biology of the major pathogens including their life cycles, transmission mechanisms, pathology, diagnosis, treatment and control. There will be an emphasis on insect transmitted diseases such as malaria, dengue and neglected diseases such as leishmaniasis. Students will discuss international public health, and specific factors that prevent successful control within economically deprived communities.

  Molecular approaches will not be covered in detail. Case study workshops will look at disease outbreaks, and practical sessions will explore and develop concepts from lectures and demonstrate some practical techniques that can be used to facilitate research into tropical diseases.

Year 4

Core

• MSci Research Project

  Together with BIOL470 MSci Project Literature Review, the projects comprise half of the final year assessment for MSci schemes. The research project allows students to spend an extended period of time in the research lab of a member of academic staff, carrying out original research and working alongside PhD students and other researchers. Students develop skills learned in the third year project to enhance student independence and provide experience of the laboratory based research environment. Students develop an adaptable, flexible, and effective approach to research questions and the ways in which their practical skills can be used to address such questions. Results of the research are reported in an 8,000 word dissertation submitted during the summer term of the final year.

Optional

• Diseases of the Brain

  This module introduces the concept of protein misfolding disorders, and expands this through consideration of two major neurodegenerative diseases; Alzheimer’s disease and Parkinson’s disease. The role of oxidative stress and proteases in neurodegenerative diseases is covered in detail, before examining the role of lipids in various brain disorders. The module also considers how animal models can be used to study both normal brain aging and neurodegenerative diseases.

• Drug Development (from concept to clinic)

  This module introduces principles involved in the discovery and development of a new drug from initial concept to the identification of a candidate compound to first use in man. This knowledge is extended by learning how the pharmaceutical industry and small biotech companies use contemporary scientific advances to identify drug targets and develop new drugs. How new drug entities are tested, developed and ultimately reach the market is examined using ‘real life’ examples in the form of case studies.

• Emerging Therapeutics in Immunology

  The aim of this module is to provide a broad understanding of the human immune system, more detailed knowledge of human immunological disorders and the application of cutting edge immunological research to biomedical science and clinical practice. Technical skills associated with this course include experience and data analysis of advanced flow cytometry techniques and insight into how research findings are reported and presented to the scientific community and media.

• Microbes and Disease

  This module aims to provide students with a broad understanding of a range of pathogens and their impact on human health, and to understand how the human body responds to these challenges. Students are also introduced to the new challenges faced by healthcare systems including emerging/re-emerging infectious diseases and antibiotic resistance and so develop an awareness of the challenges and realities of controlling infectious diseases. Students also develop an appreciation of the role of epidemiological and mathematical modelling in predicting and controlling pathogenic organisms.

• Models of Disease

  The aim of this module is to provide students with a broad understanding of the different types of model systems used in research on human diseases, an appreciation of the advantages and disadvantages of each model, and an awareness of some major discoveries that have been made using these disease models.

• Molecular Basis of Cancer

  This module provides insight into the underlying molecular events in the development of cancer, how cancers spread through the body and explain how an understanding of the molecular basis of cancer has led to the development of novel cancer treatments. Workshops allow students to study the aetiology and progression of one particular type of cancer in depth, and also to understand how cancer is studied in practice.