Dr Morgan Gadd

North West Cancer Research (NWCR) Fellow

Research Overview

My research is focused on the structure and function of protein-protein interactions (PPIs) and protein complexes. In particular I am interested in how they are formed and regulated within the cell, as well as how they can be selectively modulated by genetic and small molecule approaches. We use an interdisciplinary approach, combining techniques from synthetic chemistry to cell biology (and everything in between), in order to answer fundamental biological questions involving PPIs and develop new tools and therapies to target them.

Selected Publications

Structural basis of PROTAC cooperative recognition for selective protein degradation
Gadd, M.S., Testa, A., Lucas, X., Chan, K., Chen, W., Lamont, D.J., Zengerle, M., Ciulli, A. 31/05/2017 In: Nature Chemical Biology. 13, 5, p. 514-521. 8 p.
Journal article

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex
Cardote, T.A.F., Gadd, M.S., Ciulli, A. 6/06/2017 In: Structure. 25, 6, p. 901-911.e3. 11 p.
Journal article

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A. 23/10/2014 In: Journal of Medicinal Chemistry. 57, 20, p. 8657-8663. 7 p.
Journal article